Polarographic Studies of Pharmaceuticals. XV

Polarographic Analysis of Quetiapine in Pharmaceuticals

The voltammetric behaviour of quetiapine (QTP) was studied using direct current (DCt), differential pulse (DPP) and alternating current (ACt) polarography. The drug manifests cathodic waves over the pH range of 6 – 11.8. The waves were characterized as being irreversible, diffusion-controlled with limited adsorption properties. At pH 8, the diffusion current-concentration relationship was recti...

Polarographic Studies of Human Blood Sera

R. BrdiEka, in 1937, in a note to the editor of Nature (1), reported the application of the polarographic method to cancer diagnosis, through the measurement of certain sulphur-containing amino acids present in the proteins in human blood serum. Brdicka made tests on the serum from 67 different persons; 32 of these gave an abnormally low polarographic protein effect. These 32 cases were shown b...

Studies of Gallbladder Function. Xv. Cholesterol in Human Liver Bile.

The subject of bile drainage in the human has been very thoroughly reviewed by Fox (1) in 1928. Numerous papers have appeared, among which may be mentioned those of Walters, Green and Frederickson (2), Ravdin, Johnston, Riegel and Wright (3), and Elman and Graham (4), describing the changes occurring in hepatic bile obtained from patients with surgical drainage after the release of biliary obst...

Genetic Studies of Collagen Types Xv and Xviii

Overlapping genomic clones coding for the α1 chain of mouse type XV collagen (Col15a1) were isolated. The gene was found to be 110 kb in length and to contain 40 exons. Analysis of the proximal 5'-flanking region showed properties characteristic of a housekeeping gene promoter, and functional analysis identified cis-acting elements for both positive and negative regulation of Col15a1 gene expre...

Studies on Echinococcosis Xv : Secondary Multilocular Echinococcosis by Intrahepatic Inoculation